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The Framingham study. N Engl J Med. 1972;287:781-787. 12. Levy D, Garrison RJ, Savage DD, Kannel WB, Castelli WP. Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study. N Engl J Med. 1990;322:1561-1566. 13. Felker GM, Thompson RE, Hare JM, et al. Underlying causes and long-term survival in patients with initially unexplained cardiomyopathy. N Engl J Med. 2000;342(15):1077-1084. 14. Williams SG, Barker D, Goldspink DF, Tan LB. A reappraisal of concepts in heart failure: Central role of cardiac power reserve.

Cardiovascular regulatory mechanisms in advanced age. Physiol Rev. 1993;73: 413-467. 20. Olivetti G, Melissari M, Capasso JM, Anversa P. Cardiomyopathy of the aging human heart. Myocyte loss and reactive cellular hypertrophy. Circ Res. 1991;68:1560-1568. 21. Fleg JL, O’Connor F, Gerstenblith G, et al. Impact of age on the cardiovascular response to dynamic upright exercise in healthy men and women. J Appl Physiol. 1995;78:890-900. 22. Braunstein JB, Anderson GF, Gerstenblith G, et al. Noncardiac comorbidity increases preventable hospitalizations and mortality among Medicare beneficiaries with chronic heart failure.

71 3. 91 Some patients without outflow obstruction at rest develop gradients during physiologic and pharmacologic interventions that diminish LV end-diastolic volume or augment LV contractility. 5,99-104 One of the most frequent consequences of SAM and abnormal mitral leaflet coaptation is mitral regurgitation,60,99 which occurs in almost all patients with obstructive HCM. The regurgitant jet is usually posteriorly directed; central or anterior jets should raise the suspicion of intrinsic MV disease.

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A nonparametric procedure associated with a clinically meaningful efficacy measure (2000)(en)(6s) by Chen M.

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