By David E. Schteingart (auth.), Gary D. Hammer, Tobias Else (eds.)
This first variation of the textbook “Adrenocortical Carcinoma: uncomplicated Sciences and scientific ideas” presents a concise compilation of appropriate information advancing our present realizing of this infrequent melanoma. Chapters are devoted to a variety of points of either the fundamental biology and the scientific technology on the subject of adrenocortical carcinoma (ACC). professional clinicians introduce the reader to present state of the art medical care of sufferers with ACC. As a substantial physique of information on ACC has collected over the past many years, professional scientists have authored extra sections that function a reference resource for the skilled researcher in addition to an advent for the trainee within the laboratory or sanatorium. medical themes span the epidemiology, prognosis and treatment of ACC. clinical issues parts span the pathology and pathophysiology of ACC with a different specialise in experimental versions of adrenocortical tumors and up to date advances within the genetic facets and signaling pathways in ACC. The content material of this ebook used to be compiled and edited with the rationale of facilitating the interpretation of data into destiny diagnostic and healing instruments that might finally increase sufferer care.
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Extra resources for Adrenocortical Carcinoma: Basic Science and Clinical Concepts
Only in patients with indisputable adrenocortical steroid excess one might skip this analysis. As discussed above, ACC may rarely produce other hormones like ADH, renin, inhibin, or calcitonin. However, screening for these hormones on a routine basis is not suggested. In conclusion, the detailed endocrine work-up that was proposed by the ACC Working Group of ENSAT is recommended in all patients with suspected ACC. When applying these tests, only a minority of ACCs are hormonally inactive. 4 provides the results of the endocrine work-up in 377 patients in the German ACC Registry.
References 1. Abiven G et al (2006) Clinical and biological features in the prognosis of adrenocortical cancer: poor outcome of cortisol-secreting tumors in a series of 202 consecutive patients. J Clin Endocrinol Metab 91(7):2650–2655 2. Crucitti F et al (1996) The Italian Registry for Adrenal Cortical Carcinoma: analysis of a multiinstitutional series of 129 patients. The ACC Italian Registry Study Group. Surgery 119(2):161–170 3. Dackiw AP et al (2001) Adrenal cortical carcinoma. World J Surg 25(7):914–926 4.
J Clin Endocrinol Metab 93(5):1553–1562 48. Nieman LK et al (2008) The Diagnosis of Cushing’s Syndrome: an Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab 93(5):1526–1540 49. Boyle JG et al (2007) Comparison of diagnostic accuracy of urinary free metanephrines, vanillyl mandelic acid, and catecholamines and plasma catecholamines for diagnosis of pheochromocytoma.
Adrenocortical Carcinoma: Basic Science and Clinical Concepts by David E. Schteingart (auth.), Gary D. Hammer, Tobias Else (eds.)