New PDF release: Bone Metastases: A translational and clinical approach

By Vassiliki Tzelepi, Athanassios C. Tsamandas, Vassiliki Zolota, Chrisoula D. Scopa (auth.), Dr. Dimitrios Kardamakis MD, PhD, DMRT, Dr. Vassilios Vassiliou MD, PhD, Dr. Edward Chow MBBS, PhD, FRCPC (eds.)

ISBN-10: 1402098189

ISBN-13: 9781402098185

ISBN-10: 1402098197

ISBN-13: 9781402098192

"Bone Metastases: A Translational and scientific technique" serves as either an introductory and reference publication concentrating on the sector of metastatic bone illness. that includes contributions from specialists within the box, this quantity:

  • describes the molecular and mobile mechanisms interested by the formation of bone metastases,
  • comments at the function of angiogenesis,
  • presents the more moderen advances made within the knowing of the scientific photograph and signs of sufferers,
  • analyses the function of bone markers in examine and medical perform
  • deals with all elements of imaging modalities utilized for the detection and review of bone metastases.

This quantity additionally covers using radiotherapy, surgical procedure and systemic remedies for the administration of metastatic bone affliction and new healing techniques. additionally it may possibly additionally function a consultant for the scientific and healing administration of sufferers with metastatic bone disease.

Overall this quantity offers an intensive review of all facets of metastatic bone sickness and gives a accomplished and concise details source for clinical researchers, oncologists, orthopaedic surgeons and clinicians.

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Extra resources for Bone Metastases: A translational and clinical approach

Sample text

Cohen MM Jr. (2006) The new bone biology: pathologic, molecular, and clinical correlates. Am J Med Genet A 140A:2646–2706 7. Harada S-I, Rodan GA (2003) Control of osteoblasts function and regulation of bone mass. Nature 243:349–355 8. Franz-Odendaal TA, Hall BK, Witten PE (2006). Buried alive: how osteoblasts become osteocytes. Dev Dyn 235:176–190 9. Stains JP, Civitelli R (2005) Cell–cell interactions in regulating osteogenesis and osteoblast function. Birth Def Res C 75:72–80 10. Stains JP, Civitelli R (2005) Gap junctions in skeletal development and function.

Elasticity in cartilage is strain-rate dependent. Thus, cartilage is hard when forces are loaded rapidly, but soft when forces are applied slowly. This is attributed to the small pores formed between extracellular matrix components which enable movement of the water only when forces are applied for a few minutes or longer [39]. Growing cartilage will subsequently be replaced by bone in its entirety, apart from the epiphyseal growth plate that will be responsible for longitudinal growth of bones in prepubertal children.

Cullinane DM (2002) The role of osteocytes in bone regulation: mineral homeostasis versus mechanoreception. J Musculoskelet Neuronal Interact 2:242–244 14. Chambers TJ (2000) Regulation of the differentiation and function of osteoclasts. J Pathol 192:4–13 15. Teitelbaum SL (2000) Bone resorption by osteoclasts. Science 289:1504–1508 16. Teitelbaum SL (2000) Osteoclasts, integrins, and osteoporosis. J Bone Miner Metab 18:344–349 17. Walker DG (1972) Congenital osteopetrosis in mice cured by parabiotic union with normal siblings.

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Bone Metastases: A translational and clinical approach by Vassiliki Tzelepi, Athanassios C. Tsamandas, Vassiliki Zolota, Chrisoula D. Scopa (auth.), Dr. Dimitrios Kardamakis MD, PhD, DMRT, Dr. Vassilios Vassiliou MD, PhD, Dr. Edward Chow MBBS, PhD, FRCPC (eds.)


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